Endothelins (ETs) are a class of peptide hormones with strong vasoactive properties [Bagnato & Natali, 2004]. ETs function by interacting with their G protein-coupled receptors
(GPCRs). There are two known ET subtypes, ETA and ETB [Bremnes et al., 2000] The ETA receptor (ETAR) is localized on the plasma membrane until stimulated by endothelins such as endothelin-1 (ET-1), towards which ETAR shows the highest binding affinity...View PDF