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Utilizing PerkinElmer’s AlphaScreen technology combined with TGR Bioscience’s SureFire™ assays we have optimized an ideal screening tool for GPCRs and growth factor receptors as well as signaling pathways including MAPK. These assays provide a cell-based environment for assaying modulation of receptor activation and can also be used to measure responses of intracellular kinase inhibitors for drug discovery.
Example of how the AlphaScreen technology works with the SureFire™ technology for ERK.
Features and Benefits
- Homogenous Cellular Assays: No-wash, non-isotopic, miniaturizable cell based assays.
- Suitable for over-expressed and endogenous receptors: Extremely sensitive assay which can be used with cells over-expressing cloned targets or with cells expressing physiologically relevant endogenous levels or receptor target.
- Multiple tools to choose from: Permits interrogation of various signaling pathways, receptors and kinase targets. Please see the table below for a complete listing of products. Watch for more assays to follow!
- Use in any cell line, including primary cells: Flexible assay format and application use.
- Robotic friendly: Easy to automate the HTS-proven AlphaScreen technology. This technology is readily scaleable to 384- and 1536-well formats, while providing outstanding S/Bs and Z’ values.
Request a free AlphaScreen SureFire™ Assay sample
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