Description: A growing number of neurodegenerative diseases involve the misfolding of normal proteins in the brain. This presentation will show how synchrotron infrared imaging is used to investigate protein folding and structure within intact tissues in two neurological protein-folding diseases: scrapie (the sheep form of mad cow disease) and Alzheimer's disease. Specifically, immunofluorescence techniques and fluorescence microscopy are used to identify prion proteins and amyloid plaques in affected tissues. Then, infrared imaging is used to identify and structurally characterize misfolded protein aggregates.
Presented by Lisa M. Miller, Biophysical Chemist, from the National Synchrotron Light Source, Brookhaven National Laboratory. Her research focuses on biomedical applications of synchrotron infrared and x-ray microspectroscopy and imaging.
Duration: 51 minutes
Format: Windows Media Player
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