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Columbus Gallery

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Columbus

Opera

Columbus Logo

 

Columbus™ is a convenient and easy-to-use solution for high volume data management, storage, retrieval, visualization and protection of images and analyzed results.  Designed as a complementary product for the Opera™ platform, Columbus can import, export and manage image formats from a wide variety of sources, providing a central repository and solution for all your microscope imaging requirements.

 

 

 

Columbus data management and analysis software is available in two versions;

  • Columbus Gallery, which provides a comprehensive data archive, management and visualization solution and
  • Columbus Conductor, that includes all the functionality of Columbus Gallery, plus the ability to analyze or re-analyze HCS data from the Opera or other image data using Acapella™ image analysis software.

Columbus is ideally placed to become the industry standard for image data management.  The system utilizes the OMERO server, developed by the Open Microscopy Environment (OME).

Based on an open protocol, Columbus is able to operate with a wide variety of instruments and software so that you can place the system at the center of your volume storage requirements.

 

Columbus Gallery allows complex HCS multi-channel images to be stored and accessed by multiple users from their own workstation to view and explore with personal defined security settings, such as read/write/delete privileges for their own data and that of other users.

 

The well-centric database architecture of Columbus allows the user to browse images using relational information such as well position, Z slice and time point for kinetic experiments. In contrast to many HCS data management systems, the metadata detailing how the images were acquired, which algorithm and input parameters were used to analyze the images, the output parameters and numerical results are all stored with the image data. This means that the complete history of the experiment can be reviewed when examining the image data, so that a better understanding of the results can be obtained.

 

Columbus Conductor takes your data management system to a new level, by combining Acapella image analysis software with the Columbus Gallery functionality.  Image data can be analyzed or re-analyzed using Acapella running on the server computer, which means that you can take advantage of the greater power to run batch processes and obtain much quicker results.

Features include:

  • Set the industry standard for image data management – supports a wide range of file formats and utilizes OME technology
  • Act as a central repository for all image data – HCS, microscopy, medical images, etc.
  • Forms the bridge between
    • Instruments
    • Image analysis software
    • Screening analysis software
  • Can include a fast and flexible re-analysis tool for HCS data using Acapella image analysis software
  • Follows a standard client-server architecture – one installation of Columbus can serve an entire laboratory or department for a cost effective solution
  • True database ability:
    • Query for barcode, wells, results etc.
    • Browse for and access to data files
    • Data search/query by barcode and well position
  • Convenient, rapid and clear visualization of image sets:
    • Multiple channels
    • Multiple fields
    • Z stacks
    • Time-course
    • Navigation tools for stacks, time-course
  • Global access using OMERO.insight Viewer, a freely available application
  • Standardized data format for importing of commonly used image formats
  • Security for your HCS data through user management

Columbus Gallery provides a number of ways to navigate images. Here, a Z stack of images is browsed using slider.

Opera

Open Microscopy Environment support in Columbus HCS IMage management software

Columbus utilizes the Open Microscopy Environment (OME) which is a multi-site collaborative project among academic laboratories and a number of commercial entities that produces open tools to support data management for biological light microscopy.

View the results of your imaging-based screens as heatmap representations of the various output parameters. OMERO software is released by the OME Consortium and is ©2008 University of Dundee and Glencoe Software, Inc.

 

 

Product Support

  • Request more information
  • Request product support
  • Download Columbus Brochure

Related Products

  • Opera
  • Opera LX
  • Acapella Image Analysis Software

Opera Application Examples


Whole cell fluorescence assays

Stem cell
  • Cell viability
  • Cell differentiation
  • Cell proliferation
  • Cytotoxicity
  • Apoptosis
  • Transporter phenomena


Cell signaling assays

  • Second messengers
  • Ion channels/Membrane potential


Gene expression assays

  • Expression of house-keeping as well as reporter genes
  • Gene acitivity and protein regulation
  • RNAi screens


Membrane receptor assays

  • Ligand binding
  • Receptor activation and desensitization
  • Translocation and endocytosis
  • Recruitment of signaling molecules


Translocation assays

  • Target molecule redistribution


Morphological assays

Neurite outgrowth
  • Neurite outgrowth
  • Cell differentiation
  • Cell adhesion and spreading


Immunochemical assays

  • Bead-based homogeneous Antigen-antibody interactions


 

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