GPCR Research

Move your mouse over the image and click on a relevant area to view our GPCR solutions.

PerkinElmer offers the most comprehensive collection of G-protein-coupled receptor (GPCR) reagents and instrumentation for cellular and biochemical drug discovery. With the addition of AequoScreen® and PhotoScreen™ cell lines to the portfolio, high sensitivity calcium detection is now possible. So whatever signaling pathway you choose, we have the platforms to address all GPCR targets including technologies for the detection of: intracellular calcium, cAMP, phospho-ERK, reporter gene expression or GTP & classical ligand binding.

PerkinElmer’s optimized assay systems and reagents allow you to evaluate the activity of your candidate against a variety of GPCRs. Our technologies include essential radioisotopic , state-of -the-art luminescence and fluorescence detection systems, the instrumentation to measure signal, as well as microplates, reagents and radioligands.

GPCRs have seven transmembrane domains and tranduce an extracellular signal (ligand binding) to an intracellular signal (G protein activation), inducing a cellular response to the environment. GPCRs are a superfamily of proteins which are involved in numerous biological processes and pathological conditions. Their importance to drug discovery is evident in that they are the target of about half of the approved drugs on the market.

Move your mouse over the image and click on a relevant area to view our GPCR solutions.