PerkinElmer's Custom Synthesis Lab scientists are experts in dealing with technically challenging synthesis of radiolabeled biochemicals such as peptides, steroids, lipids, and others. Our synthesis chemists routinely collaborate with chemists from PerkinElmer's Analytical Laboratory to ensure the successful purification and analysis of final products.

Chiral synthesis and chiral separation
In pharmaceutical development, there is a growing need for chiral compounds, which may offer superior characteristics over racemic mixtures. At PerkinElmer, we are experienced in synthesizing chiral compounds, as well as performing chiral separations. With your welcomed participation, we can efficiently select the most appropriate chiral methodology for your custom solution. As the table below shows, we offer several alternatives.

Purity requirements for ¹⁴C, ³H, and ³⁵S custom synthesis
PerkinElmer analyzes every custom synthesis solution to ensure that it meets your purity requirements, which, of course, are agreed upon before you accept our quotation. When your custom radiochemical is delivered, it is accompanied by a report detailing exactly what purity analysis methods were used - HPLC; MS; NMR; GLC; UV spectrometry; HPSEC; PDA or LCMS; or agarose or polyacrylamide gel electrophoresis - and what the results are. For totally new, custom radiochemicals, the PerkinElmer Analytical Laboratory works with you and with PerkinElmer's synthesis chemists in a three-way effort to develop appropriate new analytical methods.

Polyethylene glycols (PEGs)
Polyethylene glycols (PEGs) are an increasingly valuable tool in pharmaceutical applications, including ADME studies. They readily attach to other molecules and surfaces, offering a biocompatible protective coating. With PEGs, the target molecule often retains biological activity, and rarely elicits a significant immune response. PEGs are often soluble in water and many organic solvents. What's more, in collaboration with Shearwater Polymers, PerkinElmer now offers you a variety of PEG derivatives labeled with ¹⁴C, ³H, ¹³C, and ²H, which can be provided within a specified molecular weight distribution.

	ISO 9002	Technical Data Sheets	Total Activity Measurement	Specific Activity Measurement	Radio-chemical Purity	Chiral Separation or Synthesis	GMP (upon request)
14C, 3H, 35S Custom Synthesis
14C, 3H, 35S Radioactive Fermentation Labeling
125I or 131I Radioiodination
Tritium Labeling Plus
Tritium Labeling Services
Catalytic Reduction with Tritium Gas
Reduction with Sodium Borohydride, [3H]
Catalytic Exchange with Tritium Gas
Tritium Gas Exposure
14C-Labeled Precursors

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