PhotoScreen™ (Photina®) photoproteins are a kinetic luminescence technology for measuring calcium flux in cells. It is an alternative technology to fluorescent dyes being used on the FLIPR for studying GPCR targets. The large robust signal generated lets you screen for agonists, antagonists and allosteric modulators with reduced false positives.PhotoScreen photoproteins have been isolated from the jellyfish Obelia longissima. Upon calcium binding the photoprotein oxidizes coelenterazine into colenteramide with the production of CO2 and emission of light. PhotoScreen is a chimeric photoprotein, generated from obelin and clytin, which can be used to measure calcium from Gq-, Gs- and Gi-coupled receptors as well as calcium-coupled ion channels and transporters.
PhotoScreen™ (Photina®) photoproteins are a kinetic luminescence technology for measuring calcium flux in cells. It is an alternative technology to fluorescent dyes being used on the FLIPR for studying GPCR targets. The large robust signal generated lets you screen for agonists, antagonists and allosteric modulators with reduced false positives.
PhotoScreen photoproteins have been isolated from the jellyfish Obelia longissima. Upon calcium binding the photoprotein oxidizes coelenterazine into colenteramide with the production of CO2 and emission of light. PhotoScreen is a chimeric photoprotein, generated from obelin and clytin, which can be used to measure calcium from Gq-, Gs- and Gi-coupled receptors as well as calcium-coupled ion channels and transporters.
Product number: AX-013-PCL
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GPCR Application Guide