Neuropeptide S (Human), [¹²⁵I-Tyr¹⁰]

Neuropeptide S (human), Ser-Phe-Arg-Asn-Gly-Val-Gly-Thr-Gly-Met-Lys-Lys-Thr-Ser-Phe-Gln-Arg-Ala-Lys-Ser-OH, is an identified endogenous peptide ligand for its deorphanized G-protein coupled cognate receptor.¹
Neuropeptide S is a novel neuropeptide that potently modulates arousal and could also regulate anxiety-related behavior.¹
Neuropeptide S (human), [¹²⁵I-Tyr10]- is an analog with a substitution of ¹²⁵I-Tyr10 for Met at position 10.
The Neuropeptide S receptor has been identified as a candidate target for asthma and termed "G-protein coupled receptor for asthma susceptibility" (GPRA).²

Features

K_d = 0.33 ± 0.12 nM
Bmax = 3.2 ± 0.4 fmol/150,000 cells

References

Xu, Y-N., Rainer, K.R., Huitron-Resendiz, S., Clark, S.D., Wang, Z., Lin, S.H., Brucher, F.A., Zeng, J., Ly, N.K., Henriksen, S.J., de Lecea, L., Civelli, O. Neuron 43, 487-497 (2004).
Laitinen, T., Polvi, A., Rydman, P., Vendelin, J., Pulkkinen, V., Salmikangas, P., Makela, S., Rehn, M., Priskanen, A., et al. Science 304, 300-304 (2004).